6.7 Hypothalamic and anterior pituitary hormone related disorders
| First line drugs | Second line drugs | Specialist drugs | Secondary care drugs |
Traffic light status (TLS) explained:
- Green: Routine prescribing within licensed indication
- Amber 1: specialist recommendation followed by GP initiation and continuation
- Amber 2: specialist or GP initiation in line with local guideline after 1st line failure followed by GP continuation
- Amber 3: specialist initiation and stabilisation followed by GP continuation
- Amber SCG: specialist initiation and stabilisation followed by GP continuation in line with an agreed shared care guideline
- Red: Hospital or specialist prescribing only
6.7.1 Adrenocortical function testing
Corticotrophins
Tetracosactide
- Synacthen® Injection, solution, 250 micrograms in 1mL (30 minute diagnostic test)
- Synacthen Depot® Injection, suspension, 1mg in 1mL (5 hour diagnostic test)
6.7.2 Assessment of pituitary function
Gonadorelin
(Gonadotrophin-releasing hormone; GnRH; LH-RH)
For assessment of pituitary function
- Injection 100 microgram vial with diluent
Protirelin
- Injection 100 microgram/mL
6.7.3 Gonadatrophin replacement therapy
Chorionic gonadotrophin (HCG)
- Pregnyl® Injection with solvent 1500 units, 5000 units
6.7.4 Growth hormone disorders
Somatropin (synthetic Human Growth Hormone) Amber 3
- Genotropin® Injection & Prefilled pens 5.3mg (16 units), 12mg (36 units)
Notes:
- Use as per NICE TA188: Human growth hormone (somatropin) for the treatment of growth failure in children (May 2010)
- Use as per NICE TA64: Human growth hormone (somatropin) in adults with growth hormone deficiency (August 2003)
Pegvisomant (Growth hormone receptor antagonist)
- Injection 10mg, 15mg, 20mg, 25mg, 30mg
Notes:
- Use as per NHS England Clinical Commissioning Policy for Pegvisomant for acromegaly as a third-line treatment (adults) Dec 2016
Traffic light status (TLS) explained:
- Green: Routine prescribing within licensed indication
- Amber 1: specialist recommendation followed by GP initiation and continuation
- Amber 2: specialist or GP initiation in line with local guideline after 1st line failure followed by GP continuation
- Amber 3: specialist initiation and stabilisation followed by GP continuation
- Amber SCG: specialist initiation and stabilisation followed by GP continuation in line with an agreed shared care guideline
- Red: Hospital or specialist prescribing only
Return to Chapter: 6. Endocrine System
Last updated by: Dupe Fagbenro on 21-12-2018 11:36
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BNF
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NICE
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Summary of product characteristics
