1.3 Diarrhoea
| First line drugs | Second line drugs | Specialist drugs | Secondary care drugs |
Traffic light status (TLS) explained:
- Green: Routine prescribing within licensed indication
- Amber 1: specialist recommendation followed by GP initiation and continuation
- Amber 2: specialist or GP initiation in line with local guideline after 1st line failure followed by GP continuation
- Amber 3: specialist initiation and stabilisation followed by GP continuation
- Amber SCG: specialist initiation and stabilisation followed by GP continuation in line with an agreed shared care guideline
- Red: Hospital or specialist prescribing only
Acute diarrhoea
Useful resources
1. Public Health England: Managing Suspected Infectious Diarrhoea
Antipropulsives
Loperamide hydrochloride
- Capsules 2mg
- Oral Syrup Sugar-free 1mg/5mL
- Orodispersible Tablets 2mg (Hosp use only by stoma care team)
Notes:
- Should not be prescribed in Primary Care or at Discharge
- Advise patient to purchase, unless prescription is for long-term regular use
- Drug Safety Update: MHRA Drug Safety Update: Loperamide (Imodium) - reports of serious cardiac adverse reactions with high doses of loperamide associated with abuse or misuse (September 2017)
Antimotility drugs
Eluxadoline (Amber 3)
- Truberzi® Tablets film-coated 100mg
Notes:
- Drug Safety Update: MHRA: Eluxadoline (Truberzi): risk of pancreatitis; do not use in patients who have undergone cholecystectomy or in those with biliary disorders (December 2017)
- NICE TA471: Eluxadoline for treating irritable bowel syndrome with diarrhoea (August 2017)
Return to Chapter: 1. Gastro-Intestinal System
Last updated by: Dupe Fagbenro on 20-02-2019 11:12
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BNF
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NICE
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Summary of product characteristics
